Museums
Museo Lamborghini (MUDETEC)
Situated at the Lamborghini headquarters, it displays the evolution of the brand's iconic supercars and future technology.
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Road trip route · Italy
Rome to Milan drive time, distance, costs & the best stops
- Drive time
- 6 hr
- Distance
- 572 km
- Fuel (est.)
- €74
- Tolls (est.)
- €32
The Rome to Milan drive
The drive from Rome to Milan covers 355 miles (572 km) and takes about 6 hr without stops. That's a long haul for one day, most drivers split it over two days, stopping overnight near Uffizi Gallery, which turns a slog into a proper road trip.
Expect fuel for a typical petrol car (~40 mpg) to cost around €74 one-way plus roughly €32 in motorway tolls. Prices shift monthly, so treat these as ballpark figures.
At 355 miles this is longer than 87% of the 144 routes covered here, so it is worth treating as a trip in itself rather than a transfer. Split across 2 days it works out at about 3 hours behind the wheel each day, which leaves most of the daylight for the places in between.
Best stops between Rome and Milan
Within ~30 km of the driving route, worth the detour.
Cathedrals & Temples
Florence Cathedral (Cattedrale di Santa Maria del Fiore)
Brunelleschi's magnificent terracotta dome dominates the Florence skyline and remains the largest brick dome ever constructed.
Waterfalls
Cascata delle Marmore
A 165-meter man-made waterfall created by the ancient Romans in 271 BC, now one of Italy's most impressive cascades.
Cathedrals & Temples
Orvieto
A dramatic Umbrian hill town perched atop volcanic tufa cliffs, crowned by one of Italy's most ornate Gothic cathedrals.
Museums
Museo Ferrari Maranello
The heart of the Prancing Horse empire featuring iconic Formula 1 cars, road legends, and interactive racing simulators.
Museums
Museo Enzo Ferrari Modena
Birthplace museum of Enzo Ferrari housed under a dramatic yellow aluminum hood-shaped roof celebrating the man behind the legend.
Historic Highways
Autostrada del Sole
Italy's original motorway running from Milan to Naples through Tuscany and past Rome, an icon of postwar Italian engineering.
Museums
Uffizi Gallery
Italy's foremost art gallery, housing the greatest collection of Renaissance art including Botticelli's Birth of Venus.
Landmarks
Villa d'Este (Tivoli)
A Renaissance cardinal's villa near Rome with one of the finest Italian gardens, featuring hundreds of elaborate fountains and water features.
What you need for this drive
Rules for each country on the route, in the order you meet them.
Italy
- Motorway
- 130 km/h · 50 in town
- Tolls
- Autostrade
- Must carry
- warning triangle, hi-vis vest
- Winter tyres
- 15 November - 15 April
Low-emission zones: ZTL (Zona a Traffico Limitato).
Checked against national road authorities and the ECB reference rates. Rules change — confirm before you travel.
Famous drives in Italy
Legendary routes you could bolt onto this trip, with real distances and stop counts.
Rome to Milan FAQs
How long is the drive from Rome to Milan?
Driving from Rome to Milan takes about 6 hr nonstop, covering 355 miles (572 km). Add time for breaks: most drivers stop every 2 hours.
How much does it cost to drive from Rome to Milan?
Fuel for a typical petrol car (~40 mpg) costs roughly €74 one-way. Expect around €32 in motorway tolls. Estimates are indicative: prices change monthly.
Can I drive from Rome to Milan in one day?
It's possible but long: 6 hr of driving. Most people split it over two days, with an overnight stop near Uffizi Gallery, which turns the drive into a proper road trip.
What other drives can I plan on Plan Your Road Trips?
We publish drive times, distances and fuel estimates for 144 routes across Europe and beyond, including 17 other drives in the same country. Browse them all on the routes index.
What are the best stops between Rome and Milan?
Top-rated stops in the drive corridor include Museo Lamborghini (MUDETEC), Florence Cathedral (Cattedrale di Santa Maria del Fiore), Cascata delle Marmore: see the full list of 9 stops on this page.
More drives from Rome & Milan
London → RomeMilan → FlorenceMilan → Lake ComoMilan → VeniceNice → MilanRome → AmalfiRome → FlorenceRome → NaplesRome → PisaRome → Venice
Planning a bigger trip? Try the free Italy road trip planner, browse every destination we cover, take it with you on the road, or read the driving in Italy guide.